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Published on: August 12, 2019
Tertiary amine-directed and involved carbonylative cyclizations through Pd/Cu-cocatalyzed multiple C-X (X = H or N)
Qiu-Chao Mu1,2, Yi-Xue Nie2, Xing-Feng Bai1,2
1State Key Laboratory for Oxo Synthesis and Selective Oxidation , Suzhou Research Institute (SRI) , Lanzhou Institute of Chemical Physics (LICP) , University of the Chinese Academy of Sciences (UCAS) , Lanzhou 730000 , P. R. China . Email: chenj@licp.cas.cn ;
Abstract:
A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N-dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N,N-dimethylamine group on o-indolyl-N,N-dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N,O-ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp3)-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp2)-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp3)-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ-formed directing group in the intramolecular carbonylative lactonization step.
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