Related Experiment Video
Updated: Dec 28, 2025
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
702
Psoriatic Nephropathy and its Correlation with hs-CRP: A Case Control Study.
Ishmeet Kaur1, Vijay Gandhi1, Alpana Raizada2
1Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, Delhi, India.
Indian Dermatology Online Journal
|February 15, 2020
Summary
Psoriasis patients, especially those over 30 or with long-standing disease, show reduced kidney function and subclinical albuminuria. Inflammation, indicated by hs-CRP, correlates with renal involvement in psoriasis.
Area of Science:
- Nephrology
- Dermatology
- Systemic Autoimmune Diseases
Background:
- Psoriasis is a multisystem disorder linked to cardiovascular disease, diabetes, and metabolic syndrome.
- Renal involvement in psoriasis is understudied, and its association remains unclear.
Purpose of the Study:
- To investigate causal attributable renal involvement in psoriasis patients.
- To identify factors influencing renal function in psoriasis.
Main Methods:
- Fifty psoriasis patients (excluding secondary renal disease causes) underwent routine and specific kidney function tests.
- Evaluated urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR).
- Compared results with 50 age- and sex-matched controls; assessed disease-related factors.
Main Results:
- No significant overall difference in eGFR between psoriasis patients and controls.
- Psoriasis patients over 30 showed significantly lower eGFR compared to controls (P=0.023).
- Eight percent of psoriasis patients exhibited microalbuminuria; no controls did.
Conclusions:
- Subclinical albuminuria is present in 8% of psoriasis patients.
- Reduced eGFR and glomerular dysfunction observed in psoriasis patients over 30 and those with long-standing disease.
- Positive correlation between renal involvement and hs-CRP suggests a role for inflammation.
Related Concept Videos
01:26Nephrotic Syndrome II : Assessment and Medical Management
155
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
155
01:24Nephrotic Syndrome I : Introduction
417
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
417
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
473
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
473
01:24Nephrotic Syndrome III : Nursing Management
234
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
234
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
124
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
124
01:11Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K