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Mechanisms regulating myoblast fusion: A multilevel interplay

Lilya Lehka1, Maria Jolanta Rędowicz1

  • 1Laboratory of Molecular Basis of Cell Motility, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093, Warsaw, Poland.

Seminars in Cell & Developmental Biology
|February 18, 2020
PubMed
Summary

Myoblast fusion is essential for skeletal muscle development and repair. This review details the cellular events and genetic mechanisms regulating this critical process, including links to muscle disorders.

Keywords:
AdhesionCell-cell fusionFKHRMAPKMembrane fusionMigrationMuscle pathologyMyoblastMyotubeNFATSRFSkeletal muscleWnt/β-catenin

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