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Cobalt-Catalyzed C-H Acetoxylation of Phenols with Removable Monodentate Directing Groups: Access to Pyrocatechol
Quan Gou1, Xiaoping Tan1, Mingzhong Zhang1
1School of Chemistry and Chemical Engineering, Laboratory of Natural Medicine Research and Development in Wuling Mountain, Yangtze Normal University, Chongqing 408100, China.
Abstract:
An efficient cobalt-catalyzed C-H acetoxylation of phenols has been developed by using PIDA (phenyliodine diacetate) as a sole acetoxy source to synthesize pyrocatechol derivatives for the first time. The key feature of this method is the use of earth-abundant metal cobalt as the green and inexpensive catalyst for the acetoxylation of C(sp2)-H bonds under neutral reaction conditions. Furthermore, the gram-scale reaction and late-stage functionalization demonstrated the usefulness of this method.
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