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Acute (-)-Epicatechin Consumption: Effects on Local Vasodilation Following Resistance Exercise and High-Intensity

Neil A Schwarz1, Andrew P Theodore1, Brandon R Funderburg1

  • 1Department of Health, Kinesiology and Sport, University of South Alabama, Mobile, AL 36688, USA.

Sports (Basel, Switzerland)
|February 21, 2020
PubMed
Summary

Acute (-)-epicatechin supplementation did not improve vasodilation during resistance exercise or enhance high-intensity exercise performance in humans. Further research is needed to explore potential benefits of this polyphenol.

Keywords:
CrossFitbrachial arterycocoadark chocolatedietary supplementnitric oxideperformanceresistance exercisevasodilation

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Area of Science:

  • Exercise Physiology
  • Nutritional Biochemistry
  • Sports Science

Background:

  • (-)-Epicatechin, a polyphenol, has demonstrated potential benefits for vascular health.
  • Previous research suggests (-)-epicatechin may influence nitric oxide pathways.
  • Understanding its effects on exercise performance and vasodilation is crucial for athletes and health professionals.

Purpose of the Study:

  • To investigate the acute effects of (-)-epicatechin on local vasodilation during resistance exercise.
  • To determine the impact of (-)-epicatechin supplementation on high-intensity exercise performance.
  • To evaluate the efficacy of (-)-epicatechin in enhancing physiological responses to exercise.

Main Methods:

  • Study 1: Randomized controlled trial involving 11 men performing resistance exercise with (-)-epicatechin or placebo, measuring brachial artery diameter and serum nitrate/nitrite.
  • Study 2: Randomized crossover trial with 11 participants completing a high-intensity CrossFit workout after (-)-epicatechin or placebo supplementation regimen.
  • Physiological markers and exercise performance times were recorded at various time points.

Main Results:

  • No significant differences in serum nitric oxide metabolites or brachial artery diameter were observed between (-)-epicatechin and placebo groups in Study 1.
  • A significant increase in brachial artery diameter was noted post-exercise, independent of supplementation.
  • Study 2 found no significant difference in workout completion time with (-)-epicatechin supplementation compared to placebo.

Conclusions:

  • Acute (-)-epicatechin supplementation did not enhance vasodilation in conjunction with resistance exercise.
  • (-)-Epicatechin did not improve high-intensity exercise performance in the studied population.
  • The findings suggest that under these specific conditions, (-)-epicatechin does not offer acute ergogenic benefits for vasodilation or performance.