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Progress in Microneedle-Mediated Protein Delivery.

Rezvan Jamaledin1,2, Concetta Di Natale1, Valentina Onesto1

  • 1Center for Advanced Biomaterials for Health Care, Istituto Italiano di Tecnologia (IIT@CRIB), 80125 Naples, Italy.

Journal of Clinical Medicine
|February 22, 2020
PubMed
Summary
This summary is machine-generated.

Microneedle (MN) patches offer a novel solution for transdermal protein delivery by creating micro-pathways through the skin. This review explores their fabrication and potential for industrial-scale dermal protein delivery.

Keywords:
antigen deliverydrug deliverymicroneedlesproteintransdermal

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Area of Science:

  • Biomedical Engineering
  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Transdermal drug delivery offers patient compliance advantages over conventional methods.
  • Delivering proteins via traditional transdermal patches is challenging due to the skin's stratum corneum barrier.
  • The stratum corneum limits transdermal delivery to small, lipophilic molecules.

Purpose of the Study:

  • To review fabrication methods for polymeric microneedle (MN) patches.
  • To assess the potential of MN patches for dermal protein delivery.
  • To discuss translational considerations for industrial scale-up of MN technology.

Main Methods:

  • Literature review of microneedle fabrication techniques.
  • Analysis of studies on protein delivery using microneedle patches.
  • Examination of industrial scale-up challenges and strategies for polymeric MNs.

Main Results:

  • Microneedle patches effectively perforate the stratum corneum, enabling non-invasive dermal delivery.
  • Polymeric MNs show promise for delivering therapeutic proteins across the skin barrier.
  • Key considerations for manufacturing and scaling up MN production were identified.

Conclusions:

  • Microneedle patches represent a significant advancement for transdermal protein delivery.
  • Further research and development are needed for widespread clinical and industrial application.
  • Polymeric MNs offer a viable platform for overcoming traditional transdermal delivery limitations.