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Ultrasound-Responsive Materials for Drug/Gene Delivery
Xiaowen Cai1, Yuan Jiang1, Mei Lin1
1Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Frontiers in Pharmacology
|February 22, 2020
Summary
Ultrasound-responsive materials like nanobubbles and nanoliposomes offer advanced drug and gene delivery. This review explores novel carriers and challenges to improve targeted therapies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Medical Imaging
Background:
- Ultrasound is a safe, non-invasive diagnostic and therapeutic tool with deep tissue penetration.
- Ultrasound facilitates site-specific drug/gene delivery and controlled release, gaining significant attention.
- Microbubbles are established ultrasound-responsive carriers, but novel materials are emerging.
Purpose of the Study:
- To review recent advances in novel ultrasound-responsive materials for drug/gene delivery.
- To discuss the challenges associated with these advanced delivery systems.
- To promote the development of ultrasound-responsive materials as effective carriers.
Main Methods:
- Literature review of novel ultrasound-responsive materials.
- Analysis of nanobubbles, droplets, micelles, and nanoliposomes as drug/gene carriers.
- Discussion of current challenges and future directions in the field.
Main Results:
- Nanobubbles, droplets, micelles, and nanoliposomes represent promising novel ultrasound-responsive carriers.
- These materials offer enhanced control over drug/gene release and targeting.
- Significant challenges remain in optimizing their stability, biocompatibility, and clinical translation.
Conclusions:
- Novel ultrasound-responsive materials show great potential for improving drug and gene delivery systems.
- Addressing current challenges is crucial for the successful clinical application of these technologies.
- Further research will drive the development of next-generation ultrasound-responsive delivery carriers.
