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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

383
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
383

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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
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Right temporal pole volume reduction in PTSD.

Savannah N Gosnell1, Hyuntaek Oh2, Jake Schmidt3

  • 1Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA; Michael E DeBakey VA Medical Center, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|February 22, 2020
PubMed
Summary
This summary is machine-generated.

Post-traumatic stress disorder (PTSD) is linked to reduced right temporal pole volume. This finding, observed in brain imaging, suggests a specific brain alteration associated with PTSD, distinct from other psychiatric conditions.

Keywords:
Post-traumatic stress disorder (PTSD)Right temporal poleStructural magnetic resonance imagingTrauma

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • Previous studies show altered cortical volumes in post-traumatic stress disorder (PTSD).
  • It remains unclear if these alterations are specific to PTSD or linked to comorbidities.
  • Appropriate control groups are crucial in psychiatric research.

Purpose of the Study:

  • To investigate cortical volume differences in PTSD patients compared to healthy and psychiatric controls.
  • To identify brain regions specifically associated with PTSD.
  • To determine if right temporal pole volume reduction is a unique biomarker for PTSD.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to assess brain structure.
  • 34 bilateral cortical structure volumes were analyzed using FreeSurfer.
  • Patients with PTSD (N=67) were compared to matched healthy controls (n=67) and psychiatric controls (n=67).

Main Results:

  • Ten cortical regions showed significant volume differences between PTSD and healthy controls.
  • The right temporal pole volume was significantly smaller in PTSD patients compared to both healthy and psychiatric controls.
  • This reduction in right temporal pole volume was specific to the PTSD group.

Conclusions:

  • Reduced right temporal pole volume is specifically associated with post-traumatic stress disorder (PTSD).
  • This finding underscores the importance of using carefully matched psychiatric controls in neuroimaging research.
  • Right temporal pole volume may serve as a potential neuroimaging biomarker for PTSD.