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Correlations between Microbiota Bioactivity and Bioavailability of Functional Compounds: A Mini-Review
Emanuel Vamanu1, Florentina Gatea2
1Faculty of Biotechnology, University of Agronomic Science and Veterinary Medicine, 59 Marasti blvd, 1 district, 011464 Bucharest Romania.
Biomedicines
|February 26, 2020
Summary
The human microbiota influences physiological functions through its metabolites. Probiotics like Saccharomyces cerevisiae and Lactobacillus plantarum can enhance the bioavailability and antioxidant activity of functional compounds, improving supplement efficacy.
Area of Science:
- Microbiology and Metabolomics
- Nutraceuticals and Biopharmaceuticals
Background:
- The human microbiota plays a crucial role in physiological functions via its metabolomic output.
- Microbial metabolites can correct dysbiosis and reduce oxidative stress.
- Functional components' bioavailability and bioactivity are influenced by gut microbiota interactions.
Purpose of the Study:
- To elucidate the mechanisms linking microbiota action to the bioavailability and bioactivity of functional components.
- To explore the potential of probiotics and prebiotics in enhancing nutrient absorption and therapeutic effects.
- To investigate novel formulation strategies for supplements considering gastrointestinal transit and bioaccessibility.
Main Methods:
- Review of existing literature on microbiota, metabolomics, and functional components.
- Analysis of probiotic strains (Saccharomyces cerevisiae, Lactobacillus plantarum) as delivery vehicles.
- Consideration of factors affecting biopharmaceutical value, including gastrointestinal transit and formulation compatibility.
Main Results:
- Probiotic administration, particularly as biomass enriched with phenolic acids, can increase antioxidant bioactivity.
- Specific probiotic strains may act as intermediaries to enhance the bioavailability of beneficial compounds.
- Gastrointestinal transit limitations can be leveraged to improve the biopharmaceutical value of supplements.
Conclusions:
- The human microbiota is central to optimizing the efficacy of functional components and supplements.
- Probiotics offer a promising strategy for enhancing bioavailability and bioactivity, particularly antioxidant properties.
- Innovative supplement formulation requires understanding bioaccessibility, biotransformations, and gastrointestinal transit effects.
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