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Updated: Dec 27, 2025

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
Published on: August 4, 2016
BAP1-inactivated melanocytic tumor with preserved BAP1 expression? Morphology to the rescue!
Lyn M Duncan1,2, Michael T Tetzlaff3,4
1Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Boston, Massachusetts.
Abstract:
BAP1-inactivated melanocytic tumors typically present with distinctive histopathological changes and loss of nuclear BAP1 protein expression. Rare cases exhibit the typical morphology but with preserved expression of BAP1. In the current issue of Journal of Cutaneous Pathology, Linos et al. describe such a case and provide a comprehensive molecular-genetic exploration to explain such a phenomenon.
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