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Late-Onset Inflammation in Asian Rhinoplasty Using Alloplastic Implants
Kyung-Chul Moon1, Kyu-Il Lee1, Jong-Seok Lee1
1Department of Plastic Surgery, Korea University Guro Hospital, 148 Gurodong-Gil, Guro-Ku, Seoul, 08308, South Korea.
Aesthetic Plastic Surgery
|February 27, 2020
Summary
Late-onset inflammation after rhinoplasty may stem from damaged implant capsules. Histological analysis revealed increased granulation tissue, inflammation, and mucin deposition in non-healthy capsules compared to healthy ones.
Area of Science:
- Plastic Surgery
- Histopathology
- Biomaterials Science
Background:
- Late-onset inflammation is a rare complication following rhinoplasty with alloplastic implants.
- Pathophysiological mechanisms of implant-related inflammation remain understudied.
- This study investigates differences between inflamed (non-healthy capsules, NHC) and non-inflamed (healthy capsules, HC) implant capsules.
Purpose of the Study:
- To analyze histological differences between NHC and HC in patients who underwent rhinoplasty.
- To identify potential causes of late-onset inflammation associated with alloplastic implants.
Main Methods:
- Histological analysis of 39 patient implant capsules (21 NHC, 18 HC) using hematoxylin and eosin, Masson's trichrome, colloidal iron, and CD31 staining.
- Comparison of tissue characteristics between NHC and HC groups.
Main Results:
- NHC showed increased edematous granulation tissue, inflammatory cells, and disorganized collagen compared to HC.
- Mucin deposition was observed in NHC.
- Endothelial lining cells (CD31-positive) were damaged in NHC.
Conclusions:
- Damaged capsules exhibit greater granulation tissue, inflammation, collagen degeneration, mucin deposition, and endothelial damage.
- Capsule damage is implicated as a crucial factor in late-onset inflammation after rhinoplasty.
