Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyanhydride microsphere formulation by solvent extraction.

C Bindschaedler1, K Leong, E Mathiowitz

  • 1Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge 02139.

Journal of Pharmaceutical Sciences
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is passive shoulder external range influenced by body posture or shoulder abduction angle?

Shoulder & elbow·2026
Same author

Outcomes of exertional rhabdomyolysis following high-intensity resistance training.

Internal medicine journal·2016
Same author

Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine?

Journal of controlled release : official journal of the Controlled Release Society·2013
Same author

The effects of iron supplementation in preweaning piglets.

Malaysian journal of nutrition·2012
Same author

Selectively transparent and conducting photonic crystal rear-contacts for thin-film silicon-based building integrated photovoltaics.

Optics express·2011
Same author

Acute medicine units: the current state of affairs in the North-West of England.

The journal of the Royal College of Physicians of Edinburgh·2010
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
Same journal

Recrystallization can stop nitrosamine formation in ranitidine hydrochloride.

Journal of pharmaceutical sciences·2026
See all related articles

A new solvent extraction method creates drug-loaded polyanhydride microspheres for controlled drug delivery. These microspheres effectively release dyes over extended periods, showcasing their potential for sustained therapeutic applications.

Area of Science:

  • Polymer Science
  • Materials Science
  • Pharmaceutical Technology

Background:

  • Controlled-release drug delivery systems are crucial for improving therapeutic efficacy and patient compliance.
  • Polyanhydride microspheres offer a promising platform for drug encapsulation due to their biocompatibility and tunable degradation properties.
  • Existing methods for microsphere production can involve harsh conditions or multiple steps, necessitating simpler and milder techniques.

Purpose of the Study:

  • To develop a novel, water-free solvent extraction process for producing drug-loaded polyanhydride microspheres.
  • To characterize the microspheres produced by this new method.
  • To evaluate the controlled-release capabilities of the polyanhydride microspheres.

Main Methods:

  • A solvent extraction technique was employed using a chloroform solution of polyanhydride and drug.

Related Experiment Videos

  • The solution was added to a stirred silicone oil phase containing suspended surfactant droplets.
  • The process was conducted without chemical reactions, heating, or contact with water.

    • Main Results:

    • The solvent extraction process successfully produced drug-loaded polyanhydride microspheres.
    • The microspheres were characterized for their morphology and drug-loading capacity (data not shown).
    • In vitro release studies demonstrated prolonged release of various dyes from the polyanhydride microspheres over extended periods.

    Conclusions:

    • A novel, mild solvent extraction process has been successfully developed for the fabrication of polyanhydride microspheres.
    • The developed method is suitable for producing drug-loaded microspheres for controlled-release applications.
    • The polyanhydride microspheres exhibit excellent sustained release properties, indicating their potential in drug delivery systems.