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Curcumin Preparations Can Improve Flow-Mediated Dilation and Endothelial Function: A Meta-Analysis.

Khalid Hamid Changal1, Muhammad Shayan Khan2, Rehana Bashir3

  • 1Cardiovascular Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA, khalid.changal@utoledo.edu.

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|February 27, 2020
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Summary
This summary is machine-generated.

Curcumin supplements significantly improve flow-mediated dilation (FMD), a marker of endothelial function, according to a meta-analysis. However, this positive effect on FMD was less pronounced in smokers.

Keywords:
CurcuminEndothelial dysfunctionFlow-mediated dilation

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Area of Science:

  • Cardiovascular Research
  • Nutraceutical Science
  • Medical Research

Background:

  • Endothelial dysfunction is an early indicator of atherosclerosis.
  • Flow-mediated dilation (FMD) assessed via ultrasonography is a key measure of endothelial function.
  • Curcumin, derived from turmeric, is investigated for its potential to improve FMD and mitigate endothelial dysfunction.

Purpose of the Study:

  • To systematically review and meta-analyze the impact of curcumin preparations on endothelial function, specifically FMD.
  • To quantify the effect size of curcumin supplementation on FMD.

Main Methods:

  • A meta-analysis of five randomized clinical trials was conducted.
  • The primary outcome measured was the improvement in brachial artery FMD post-curcumin supplementation compared to control groups.
  • Standardized mean difference and Hedges' g were used to calculate effect size, with publication bias also assessed.

Main Results:

  • Curcumin preparations demonstrated a large, positive overall effect size (ES=1.379, Hedges' g=1.353) on FMD.
  • The improvement in FMD was significantly greater in non-smokers (ES=1.639) compared to smokers (ES=0.379).

Conclusions:

  • This meta-analysis confirms that curcumin preparations significantly enhance FMD compared to placebo, thereby improving endothelial function.
  • The beneficial effects of curcumin on FMD appear to be less pronounced in individuals who smoke.