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Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
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Post-Procedure Protocols Following Platelet-Rich Plasma Injections for Tendinopathy: A Systematic Review.

Christine Townsend1, Kristian J Von Rickenbach1, Zachary Bailowitz1

  • 1Department of Rehabilitation Medicine, New York-Presbyterian Rehabilitation Medicine, Weill Cornell Medical College & Columbia University Irving Medical Center, New York, NY, USA.

PM & R : the Journal of Injury, Function, and Rehabilitation
|February 28, 2020
PubMed
Summary

Post-platelet-rich plasma (PRP) protocols for tendinopathy show significant variation. Understanding these diverse rehabilitation strategies is crucial for optimizing PRP treatment outcomes in patients with tendon injuries.

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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Sports Medicine

Background:

  • Platelet-rich plasma (PRP) is increasingly explored for tendinopathy treatment.
  • Post-injection protocols significantly influence PRP therapy outcomes.
  • Heterogeneity in post-PRP protocols may impact treatment efficacy.

Purpose of the Study:

  • To systematically review and analyze post-PRP protocols used for tendinopathy.
  • To identify common practices and variations in rehabilitation following PRP injections.
  • To highlight the lack of standardization in post-PRP care.

Main Methods:

  • Systematized literature review of MEDLINE and Embase databases.
  • Inclusion of English-language studies on adult tendinopathy patients receiving PRP.
  • Extraction of protocol specifics: NSAID use, weight-bearing, orthoses, activity modification, and rehabilitation.

Main Results:

  • Eighty-four studies met inclusion criteria, revealing significant protocol heterogeneity.
  • Weight-bearing restrictions were rare (12%); orthosis use was uncommon (18%).
  • Stretching (51%) and strengthening (54%) were common, typically starting within 2-7 days and 2-3 weeks, respectively. Postinjection NSAID restriction (56%) was more frequent than preinjection (20%). Return to activity was reported in 42% of protocols, often at 4-6 weeks.

Conclusions:

  • Substantial heterogeneity exists in post-PRP protocols for tendinopathy.
  • Limited consensus and evidence support specific post-PRP recommendations.
  • Further research is needed to establish standardized, evidence-based post-PRP rehabilitation strategies.