Recent Advances in the Construction of Trifluoromethyl-Containing Spirooxindoles through Cycloaddition Reactions
Hou-Ze Gui1, Yin Wei2, Min Shi1,2,3
1Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Meilong Road No.130, Shanghai, 200237, China.
Abstract:
The spirooxindole unit is one of the most widely investigated compound skeletons existing in numerous natural and pharmaceutical molecules. Thus, a large number of synthetic methodologies have already been reported to construct such a core structure. The trifluoromethyl group is another privileged unit in organic chemistry. The introduction of a CF3 group to an organic framework can significantly improve the properties of the molecule. In this context, an efficient approach for the construction of trifluoromethyl-containing spirooxindoles becomes a promising research direction among communities of industry and academia. In this Minireview, recent advances in the construction of trifluoromethyl-containing spirooxindoles have been summarized and discussed. In addition, representative synthetic methodologies and the corresponding reaction mechanisms have been described as well.
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