Estrogen and Bisphenol A in Hypertension.
Zena Wehbe1, Suzanne A Nasser2, Ahmed El-Yazbi3,4
1Department of Biology, American University of Beirut, Beirut, Lebanon.
Current Hypertension Reports
|March 2, 2020
Summary
Bisphenol A (BPA), an endocrine disruptor, is linked to cardiovascular disease (CVD) and hypertension. Its effects on blood pressure are specific to dose, gender, and developmental stage, requiring further research.
Area of Science:
- Endocrinology
- Cardiovascular Science
- Toxicology
Background:
- Cardiovascular disease (CVD) is a major global health concern.
- Endocrine disruptors, like bisphenol A (BPA), are implicated in CVD development.
- BPA's estrogenic structure suggests potential cardiovascular effects.
Purpose of the Study:
- To review existing research on BPA and hypertension.
- To explore the genomic, non-genomic, molecular, and cellular mechanisms of BPA's cardiovascular effects.
- To understand BPA's role as a cardiovascular estrogenic disruptor.
Main Methods:
- Literature review of studies on BPA and cardiovascular health.
- Analysis of mechanisms involving estrogen receptors (ERs) in cardiovascular physiology.
- Examination of factors influencing BPA's effects, including dose, gender, tissue, and developmental stage.
Main Results:
- BPA interacts with estrogen receptors, impacting estrogen-regulated phenotypes.
- Existing evidence suggests BPA adversely affects blood pressure.
- BPA's hypertensive effects are dose-dependent, gender-specific, and time-specific.
Conclusions:
- BPA acts as a cardiovascular estrogenic disruptor, contributing to hypertension.
- Further comprehensive studies are needed to fully understand BPA's complex effects on blood pressure.
- Epigenetic factors and other parameters must be considered in future research.
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