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Updated: Dec 27, 2025

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
Published on: March 1, 2022
On biological availability dependent bone remodeling
Areti Papastavrou1, Ina Schmidt1, Paul Steinmann2
1Faculty of Mechanical Engineering, Nuremberg Tech, Nuremberg, Germany.
Abstract:
Modeling the evolution of bone density is relevant for understanding, simulation and possible prediction of bone response to external and internal influences. In this work we present a formulation for the bone density evolution process that takes into account not only the commonly considered mechanical stimulus, but, as novelty, also the influence of the availability of nutrients and hormones, with its implementation pursued within the finite element method. A simple uni-axial extension test is used to illustrate and compare our novel model against the classical approach. The results of the proposed modified model are promising for application to real-life problems.
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