Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.7K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

4.8K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
4.8K
The Bone Matrix01:18

The Bone Matrix

5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deblurring structural edges in variable thickness topology optimization via density-gradient-informed projection.

Structural and multidisciplinary optimization : journal of the International Society for Structural and Multidisciplinary Optimization·2026
Same author

Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness.

Scientific reports·2026
Same author

Multimodal mechanical characterization pipeline for spinal cord tissue.

Acta biomaterialia·2026
Same author

A novel multi-thickness topology optimization method for balancing structural performance and manufacturability.

Structural and multidisciplinary optimization : journal of the International Society for Structural and Multidisciplinary Optimization·2026
Same author

Definitive Airway Management in the Critical Care Transport Medicine Environment: An Exploratory Convenience Survey-Based Analysis of Retrieval Experts on the Profound Shock State Patient.

Air medical journal·2026
Same author

In vivo wideband MR elastography for assessing age-related viscoelasticity changes of the human brain.

Acta biomaterialia·2026
Same journal

An interpretable, clinically-aligned AI paradigm for VTE risk prediction: an approach using LLMs and compound attention.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Effects of different resistance loads during resisted sprint running on internal stresses of the ankle joint: a finite element analysis.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Analysis of typical cases of medical infusion pump metering acceptance in nursing scenarios.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Investigation of biomechanical effect of inverted orthotic insoles on flexible flatfeet.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

FeuNet: cross-user gesture recognition and fingertip force estimation network based on feature enhancement and U-Net.

Computer methods in biomechanics and biomedical engineering·2026
Same journal

Both chronological age and individual differences in aging are the two indispensable components for predicting biological age.

Computer methods in biomechanics and biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Dec 27, 2025

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.6K

On biological availability dependent bone remodeling.

Areti Papastavrou1, Ina Schmidt1, Paul Steinmann2

  • 1Faculty of Mechanical Engineering, Nuremberg Tech, Nuremberg, Germany.

Computer Methods in Biomechanics and Biomedical Engineering
|March 5, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a new bone density model that includes mechanical factors, nutrients, and hormones. The enhanced model shows promising results for predicting bone changes in real-world scenarios.

Keywords:
Bone remodelingbiological availabilitydensity changefinite element methodgrowth

More Related Videos

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.8K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

7.2K

Related Experiment Videos

Last Updated: Dec 27, 2025

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.6K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.8K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

7.2K

Area of Science:

  • Biomechanical Engineering
  • Computational Biology
  • Physiology

Background:

  • Bone density evolution is crucial for understanding bone health and predicting responses to various stimuli.
  • Current models primarily focus on mechanical stimuli, potentially overlooking other significant biological factors.
  • Accurate modeling is essential for clinical applications and therapeutic interventions.

Purpose of the Study:

  • To develop and implement a novel computational model for bone density evolution.
  • To incorporate the influence of mechanical stimuli, nutrient availability, and hormonal factors into bone remodeling.
  • To compare the predictive capabilities of the new model against traditional approaches.

Main Methods:

  • Formulation of a new bone density evolution model.
  • Integration of mechanical, nutrient, and hormonal stimuli.
  • Implementation within the finite element method (FEM) framework.
  • Validation using a simple uni-axial extension test.

Main Results:

  • The proposed model successfully integrates mechanical, nutrient, and hormonal influences on bone density.
  • Comparative analysis demonstrated the enhanced model's potential over classical approaches.
  • Simulations indicated promising predictive accuracy for bone remodeling processes.

Conclusions:

  • The novel bone density evolution model offers a more comprehensive understanding of bone remodeling.
  • Incorporating biological factors like nutrients and hormones enhances predictive power.
  • The model shows significant potential for real-life biomechanical and clinical applications.