Ring Expansion to 6-, 7-, and 8-Membered Benzosilacycles through Strain-Release Silicon-Based Cross-Coupling
Ying Qin1, Jie-Lian Han1, Cheng-Wei Ju1
1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
Abstract:
The synthesis of silacycles is highly appealing due to their important applications in organic synthesis, medicinal chemistry, and materials chemistry. However, sila-tetralins and sila-benzosuberanes are surprisingly under-represented due to a lack of general methods to access these compounds. We successfully developed a Pd-catalyzed strain-release silicon-based cross-coupling as an unprecedented ring-expansion method, which constitutes a general route for preparing diverse sila-tetralins and sila-benzosuberanes.
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