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Total synthesis of isatindigotindoline C
Juha H Siitonen1, Sherlin Lira, Muhammed Yousufuddin
1Department of Chemistry, Rice University, 6500 Main Street, Houston, TX 77030, USA. juha.siitonen@rice.edu laszlo.kurti@rice.edu.
Organic & Biomolecular Chemistry
|March 7, 2020
Abstract:
Total synthesis of isatindigotindoline C, a 3,3'-spiropyrrolidine oxindole alkaloid, is achieved in two steps using an exo-selective decarboxylative 1,3-dipolar cycloaddition as the key step. The synthesis verifies the originally assigned relative anti-stereochemistry for the bis-oxindole core of isatindigotindoline C.
