[PRACTICE OF MANAGEMENT OF PATIENTS WITH INFECTIOUS ENDOCARDITIS IN CONDITIONS OF LOW FREQUENCY OF ETIOLOGICALLY...

Area of Science:

• Infectious Diseases
• Cardiology
• Pharmacology

Background:

• Infective endocarditis (IE) management requires understanding local etiological factors and antibiotic resistance patterns.
• The Russian Federation presents a unique epidemiological landscape for IE, necessitating specific research.
• Current IE treatment practices in Russia are under examination due to low pathogen detection rates.

Purpose of the Study:

• To analyze the current management practices for infective endocarditis patients in the Russian Federation.
• To investigate the etiology, antibiotic sensitivity, and pharmacoepidemiology of IE within the Russian context.
• To assess treatment strategies in light of low frequencies of etiologically significant pathogens.

Main Methods:

• A multicenter study encompassing both retrospective and prospective patient data.
• Inclusion criteria: patients of all ages and sexes diagnosed with definite or probable infective endocarditis.
• Analysis of 406 IE cases, focusing on pathogen identification, antibiotic use, and treatment modifications.

Main Results:

• Etiologically significant pathogens were identified in 35.5% of cases (144/406).
• Gram-positive cocci predominated (90.3%), with Staphylococcus aureus being the most frequent (46.5% of isolates).
• Initial antimicrobial therapy commonly included aminoglycosides (22.8%), third-generation parenteral cephalosporins (22.1%), and glycopeptides (14.5%).

Conclusions:

• Gram-positive cocci, especially Staphylococcus aureus, are the primary pathogens in Russian infective endocarditis cases.
• Antibiotic prescribing patterns reveal frequent use of aminoglycosides, cephalosporins, and glycopeptides, with shifts observed upon treatment modification.
• Further research is needed to optimize IE management strategies in regions with challenging pathogen identification.