[SURGICALLY CAUSED INJURY AND WOUND-HEALING PROPERTIES OF BETULIN (EXPERIMENTAL STUDY)]

According to the experimental data a triterpene alcohol betulin have anti-inflammatory, wound- and burn-healing activity. Previous data reports, that betulin was used in not less than 5% concentrations. That is why studying less concentrations is of major interest. The goal of this investigation is to study anti-inflammatory properties of betulin-containing ointments on models of full-thickness skin and burn wounds. Betulin activity was studied on 170 white outbred rats with a back full-thickness skin wounds and 15 rabbits with ear skin burns. Efficiency of preparations was estimated according to a speed of wound (burn) surface reduction, time of a scab rejection (for wounds), character of hyperaemia reduction (for burns), histological data of wound (burn) preparations on the 7, 14 and 21 (3, 8 and 13) days and complete healing time of wound. Betulin-containing 0,2%, 0,5% and 5% ointments were studied. The highest wound-healing activity has shown 0,5% betulinic ointment. Burn-healing effects of 0,5% betulin-containing ointment were also more expressed, than in other groups. Full epithelization of wounds was seen on the 7 day (p=0,02). Speed of burn surface reduction of treated with 0,5% betulinic ointment was equal to that treated with «Pantenol», and even surpassed it according to histological data.