MODERN ASPECTS OF ETIOPATHOGENESIS, DIAGNOSIS, CLINICAL COURSE AND TREATMENT OF SPORADIC INCLUSION BODY MYOSITIS.

Area of Science:

• Neurology
• Immunology
• Genetics

Background:

• Sporadic inclusion body myositis (IBM) is the most frequent inflammatory myopathy in middle-aged and elderly individuals.
• IBM presents diagnostic challenges, with prevalence varying by geography, ethnicity, and age.
• Disease incidence has tripled in the last 50 years, yet its etiology and pathogenesis remain poorly understood.

Purpose of the Study:

• To review, summarize, and analyze the latest medical literature on IBM.
• To consolidate information on etiopathogenesis, clinical phenotypes, global prevalence, genetic predisposition, diagnostic criteria, and treatment trends.
• To contribute to improving diagnostic and therapeutic methods for IBM.

Main Methods:

• Comprehensive literature review of recent medical publications on IBM.
• Analysis of data on prevalence, genetics, clinical presentation, and treatment efficacy.
• Synthesis of findings to identify gaps in knowledge and areas for clinical improvement.

Main Results:

• IBM is characterized by progressive muscle weakness and atrophy, often affecting distal muscles.
• Current diagnostic criteria and treatment algorithms for other inflammatory myopathies are often ineffective for IBM.
• Significant gaps exist in understanding the underlying mechanisms and genetic factors contributing to IBM.

Conclusions:

• There is a critical need for improved diagnostic approaches and effective treatments for IBM.
• Further research into the etiopathogenesis and genetic predisposition of IBM is essential.
• This review provides a foundation for advancing clinical practice and patient care for IBM.