PPG Sensor Contact Pressure Should Be Taken Into Account for Cuff-Less Blood Pressure Measurement

Photo-plethysmography (PPG) sensors are often used to detect pulse transit time (PTT) for potential cuff-less blood pressure (BP) measurement. It is known that the contact pressure (CP) of the PPG sensor markedly alters the PPG waveform amplitude. The objective was to test the hypothesis that PTT detected via PPG sensors is likewise impacted by CP.

A device was built to measure the time delay between ECG and finger PPG waveforms (i.e., pulse arrival time (PAT) - a popular surrogate of PTT) and the PPG sensor CP at different CP levels. These measurements and finger cuff BP were recorded while the CP was slowly varied in 17 healthy subjects.

Over a physiologic range of CP, the maximum deviations of PAT detected at the PPG foot and peak were 22±2 and 40±7 ms (p<0.05), which translate to ∼11 and ∼20 mmHg BP error based on the literature. The curve relating PAT detected at the PPG foot to CP was U-shaped with minimum near finger diastolic BP. A conceptual model accounting for finger artery viscoelasticity and nonlinearity explained this curve.

Since the regulatory bias error for BP measurement is limited to 5 mmHg, PPG sensor CP should be taken into account for cuff-less BP measurement via PTT.

This study suggests that widely pursued PPG-based BP measurement devices including those that detect PTT should maintain the CP or include a CP measurement in the calibration equation for deriving BP.