Air pollution by NO₂ is associated with the risk of Bell's palsy: A nested case-controlled study

This study investigated the relationship of weather and air pollution with the onset of Bell's palsy. The Korean Health Insurance Review and Assessment Service-National Sample Cohort (HIRA-NSC) data from 2002 through 2013 were used. The 3,935 Bell's palsy patients were matched with 15,740 control participants. The meteorological data, including daily mean temperature (°C), daily mean highest temperature (°C), daily mean lowest temperature (°C), daily mean temperature difference (°C), relative humidity (%), spot atmospheric pressure (hPa), sulfur dioxide (SO₂) (ppm), nitrogen dioxide (NO₂) (ppm), ozone (O₃) (ppm), carbon monoxide (CO) (ppm), and PM₁₀ (particulate matter ≤ 10 μg/m³) for 60 days, 30 days, 14 days, 7 days, and 3 days prior to the index date were analyzed for Bell's palsy cases and controls. Conditional logistic regression analysis was used to estimate the odds ratios (ORs) of the association between the meteorological data and Bell's palsy. The mean NO₂ and PM₁₀ concentrations for 60 days were higher, while that of O₃ was lower in the Bell's palsy group than in the control group (both P < 0.001). The Bell's palsy group showed 16.63-fold higher odds of NO₂ for 60 days (0.1 ppm) than the control group (95% CI = 10.18-27.16, P < 0.001). The ORs of PM₁₀, and O₃ for 60 days showed inconsistent results according to the included variables. Bell's palsy was related to high concentrations of NO₂.