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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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[Intertriginous psoriasis].

C Thomas1, M Matthies1, B Homey1

  • 1Klinik für Dermatologie, Medizinische Fakultät, Heinrich-Heine-Universität, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 8, 2020
PubMed
Summary
This summary is machine-generated.

Intertriginous psoriasis, affecting skin folds, causes significant patient distress. Ixekizumab shows promise as a systemic treatment for this challenging condition.

Keywords:
CandidaGenital psoriasisInterleukin-17A antagonistInverse psoriasisPsychological distress

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Area of Science:

  • Dermatology
  • Immunology
  • Psychodermatology

Background:

  • Intertriginous psoriasis is a variant of psoriasis characterized by inflammatory lesions in skin folds.
  • This condition can lead to shame, stigmatization, social isolation, and mental health issues in patients.
  • There is a lack of consensus on the definition and varying prevalence rates reported for intertriginous psoriasis.

Purpose of the Study:

  • To review the challenges in defining and managing intertriginous psoriasis.
  • To explore current and potential therapeutic options for intertriginous psoriasis.

Main Methods:

  • Literature review on intertriginous psoriasis definitions, prevalence, and treatment.
  • Analysis of existing data on topical and systemic treatment efficacy.

Main Results:

  • Therapeutic management of intertriginous psoriasis is challenging due to lesion location.
  • Mild symptoms are typically managed with topical corticosteroids or immunomodulators.
  • Encouraging efficacy data exists for ixekizumab, suggesting its potential as a systemic treatment.

Conclusions:

  • Intertriginous psoriasis presents unique diagnostic and therapeutic challenges.
  • Ixekizumab demonstrates potential as an effective systemic therapy, offering a new treatment avenue.