Reducing urinary oxalate by simultaneous using Sankol herbal drop with oxalate-degrading bacteria

Hyperoxaluria remains a poorly understood condition with limited therapeutic options. Prior research has shown that elevated urinary oxalate contributes to kidney stone formation. Ethylene glycol-induced models have demonstrated how oxalate accumulates in urine. Conventional treatments focus on dietary restriction or pharmacological agents. Herbal remedies like Sankol have been traditionally used for urinary health. Probiotics capable of degrading oxalate have emerged as a potential intervention. This gap motivated exploring combinations of herbal and microbial approaches. No prior work had resolved how these two interventions might interact. This paper introduces a novel dual-approach strategy for managing hyperoxaluria.

This study aimed to test a new treatment strategy for hyperoxaluria. The specific problem is the lack of effective interventions to lower urinary oxalate. The motivation comes from traditional use of Sankol and recent interest in oxalate-degrading bacteria. Researchers wanted to determine if combining these two approaches could enhance effectiveness. The study focused on a rat model of ethylene glycol-induced hyperoxaluria. The goal was to measure urinary oxalate levels after treatment. The design included six experimental groups with varying interventions. This approach allowed direct comparison of Sankol and probiotic effects.

The study used male Wistar rats divided into six groups. One group served as a positive control with normal diet and ethanol. Five groups received ethylene glycol to induce hyperoxaluria. Two groups received Sankol at minimum and maximum concentrations. Two additional groups received Sankol plus probiotics. The bacterial strains included Lactobacillus, Bifidobacterium, and L. paracasei. These bacteria were selected for strong oxalate-degrading ability in vitro. Urinary oxalate levels were measured after 30 days of treatment. The study also assessed calcium oxalate crystal formation in urine samples.

The combination of Sankol and probiotics significantly reduced urinary oxalate. Maximum concentration Sankol plus probiotics showed the strongest effect (P = 0.0001). Rats in the negative control group had high levels of CaOx crystals. Rats in the combined treatment group showed no CaOx crystals. Sankol alone at maximum concentration also reduced oxalate, but less than with probiotics. Minimum concentration Sankol had a smaller effect on oxalate levels. Probiotics alone did not significantly lower oxalate in this model. These findings suggest a synergistic interaction between Sankol and oxalate-degrading bacteria.

The authors propose that combining Sankol and oxalate-degrading bacteria may reduce urinary oxalate. This is the first study to show this effect in a rat model of hyperoxaluria. The strongest reduction occurred with maximum Sankol concentration and probiotics. The absence of CaOx crystals in treated rats suggests effective oxalate reduction. The study does not claim that this combination is essential for all hyperoxaluria cases. The findings suggest a potential new approach for managing this condition. The authors do not propose this as a definitive treatment but as a promising strategy. Further research is not discussed in the abstract, but the results suggest potential clinical relevance.