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Updated: Dec 26, 2025

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
Evolution of Neuroendocrine Tumor Therapy
Thomas M O'Dorisio1, Alan G Harris2, M Sue O'Dorisio3
1Division of Endocrinology, University of Iowa Hospitals and Clinics, Room E401-5 GH, 200 Hawkins Drive, Iowa City, Iowa 52242, USA.
Abstract:
To better understand developments in treatment of neuroendocrine tumors of the gastroenteropancreatic system, and the pivotal roles of native somatostatin and its long-acting analogues play in normal peptide regulation and neuropeptide excess associated with neuroendocrine tumors (NETs), this article delineates and defines distinct eras in the history and discovery of gastrointestinal endocrinology. We highlight the collaboration between academia and industry in basic science and the clinical research that advanced Lu-177-DOTATATE to approval as standard of care therapy for low-grade NETs. Examples of new radioisotopes and therapy compounds currently in development for diagnosis and therapy for high-grade NETs are also discussed.
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