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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Updated: Dec 26, 2025

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells
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[Cellular therapies].

Andreas Holbro1,2, Dominik Heim1, Astrid Tschan-Plessl1,3

  • 1Klinik für Hämatologie, Universitätsspital Basel.

Therapeutische Umschau. Revue Therapeutique
|March 12, 2020
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Summary
This summary is machine-generated.

Chimeric antigen receptor (CAR) T-cell therapy represents a breakthrough in cellular therapies for malignancies. This review details CAR T-cell structure, manufacturing, treatment, and future directions in the field.

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Area of Science:

  • Hematology
  • Immunotherapy
  • Oncology

Background:

  • Established cellular therapies like transfusion medicine and stem cell transplantation are crucial in hematology.
  • Decades of research focused on reprogramming the patient's immune system to combat malignancies.
  • Chimeric antigen receptor (CAR) T-cells have emerged as a significant advancement.

Purpose of the Study:

  • To review the structure and manufacturing processes of CAR T-cells.
  • To outline the current steps involved in CAR T-cell treatment.
  • To provide an outlook on future prospects and challenges in cellular therapies.

Main Methods:

  • Review of current literature on CAR T-cell therapy.
  • Discussion of the genetic engineering of T-cells to target tumor antigens.
  • Analysis of established CAR T-cell treatment protocols.

Main Results:

  • CAR T-cells are genetically engineered to target specific tumor antigens.
  • The review details the manufacturing and treatment phases of CAR T-cell therapy.
  • Current licensing and protocols for CAR T-cell treatment are discussed.

Conclusions:

  • CAR T-cell therapy is a pivotal development in harnessing the immune system against cancer.
  • Understanding CAR T-cell structure, manufacturing, and treatment is key.
  • Future research should address challenges and expand the scope of cellular therapies.