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Cannabis and the Cornea.

Anne X Nguyen1, Albert Y Wu2

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Summary
This summary is machine-generated.

Cannabinoids may reduce corneal pain and inflammation, but can also cause corneal dysfunction. Further research is needed to develop safe cannabinoid treatments for eye conditions.

Keywords:
Cannabinoidscannabiscorneacorneal hyperalgesiacorneal inflammation

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Neuroscience

Background:

  • Cannabis legalization is increasing, necessitating an understanding of its ocular effects.
  • Cannabinoids show potential for pain relief but may cause adverse effects.

Purpose of the Study:

  • To review the effects of cannabinoids on the cornea.
  • To examine the anti-nociceptive and anti-inflammatory properties of cannabinoids in ocular tissues.

Main Methods:

  • Systematic review of studies on cannabis and the cornea.
  • Literature search of NCBI databases from 1781 to December 2019.

Main Results:

  • Five studies reported corneal dysfunctions, including opacification and reduced endothelial cell density.
  • Twelve studies indicated a reduction in corneal pain and inflammation, with decreased lymphocytes and neovascularization.

Conclusions:

  • Over half of the reviewed studies highlighted therapeutic effects of cannabinoids on the cornea.
  • The field requires further investigation to establish safe cannabinoid-based therapies for corneal diseases.