MMHub, a database for the mulberry metabolome.

Area of Science:

• Plant metabolomics
• Agricultural science
• Traditional medicine

Background:

• Mulberry (Morus spp.) is a vital economic crop and traditional medicine.
• It possesses a rich profile of bioactive compounds, including flavonoids, amino acids, alkaloids, and vitamins.
• Growing interest in mulberry's applications necessitates comprehensive data on its chemical constituents.

Purpose of the Study:

• To establish the first public repository for mass spectral data of small chemical compounds in mulberry leaves.
• To provide a centralized resource for metabolomic analysis of mulberry.
• To facilitate the identification and characterization of mulberry metabolites.

Main Methods:

• Collected 936 electrospray ionization tandem mass spectrometry (ESI-MS2) datasets from 91 mulberry resources.
• Identified or tentatively annotated 124 metabolites.
• Deposited structural details for 90 metabolites in the MMHub database.
• Included supporting data such as PubChem information, molecular formulas, and metabolite classifications.

Main Results:

• The MMHub database (version 1.0) is now publicly accessible.
• It contains ESI-MS2 data and distribution information for 124 identified metabolites in mulberry.
• Detailed chemical structures and spectral tags are available for 90 metabolites.

Conclusions:

• MMHub offers crucial, comprehensive metabolome data for mulberry research.
• This resource supports the screening of high-quality mulberry varieties and specific metabolites.
• It advances the understanding and utilization of mulberry's bioactive compounds.