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Updated: Dec 26, 2025
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
Myelodysplastic Syndrome with Complex Chromosomal Abnormalities: A Case Report and Literature Review
Pengfei Feng1, Xiulian Zhang1, Yunfeng Gu1
1Department of Hematology, The First Hospital of Shanxi Medical University, Taiyuan, Chian, China.
Objective:
Karyotype is the most important diagnostic and prognostic parameter in myelodys-plastic syndrome (MDS). Here, we describe a novel case of MDS with complex chromosomal abnormalities.
Case Presentation:
A 55-year-old Chinese female was admitted to the hospital for facial edema and a loss of appetite. Bone marrow aspiration showed the blast cell count 3.6%. Erythrocyte hyperplasia was active, megaloblastoid change was observed, and a wide variability of nuclear numbers, as well as variability of size and shape was present. Bone marrow chromosomal analyses showed 45~48, X, -X, -4, t (5;8) (q13;q22), add (7) (q11), add (13) (p11), -14, del (16) (p13), add (19) (q13), -20, i(21)(q10),+4~6mar [cp15]/46,XX[5]. The patient was diagnosed with MDS with WPSS of the high risk group. IPSS was medium risk-2. IPSS-R was categorized as the extremely high risk group.
Conclusion:
The prognosis and treatment of MDS with complex chromosomal abnormalities are still uncertain, and further studies are needed.
