Related Experiment Video
Updated: Dec 26, 2025

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
Published on: March 20, 2013
Reversible redox-responsive 1H/19F MRI molecular probes
Hongming Chen1, Xiaoxue Tang1, Xuanqing Gong1
1State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. hylin007@xmu.edu.cn jhgao@xmu.edu.cn.
Abstract:
Herein we report a pair of redox-responsive manganese complexes Mn(iii)/(ii)-N,N'-bis(2-hydroxy-4-trifluoromethylbenzyl)ethylenediamine-N,N'-diacetate (HTFBED, L1), which are water soluble and biologically interconvertible, as reversible redox-responsive probes in 1H/19F MRI for detecting and imaging biological redox species, offering a means to access valuable redox information associated with various diseases.
Related Concept Videos
Magnetic Resonance Imaging
Double Resonance Techniques: Overview
Spin decoupling is usually achieved by...
Applications Of NMR In Biology
Other Nuclides: 31P, 19F, 15N NMR
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...

