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Updated: Dec 26, 2025

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Are Adverse Events Attributed to Essure Associated With Nickel Sensitization?
Nadia Raison-Peyron1, Aurélie Du-Thanh1, Clara Compan2
1From the Department of Dermatology, Allergology Unit.
Background:
Essure is an effective method for hysteroscopic sterilization. Reports of adverse effects, the underlying mechanisms of which are unknown, have increased in recent years.
Objective:
The aim of the study was to determine whether there is a relationship between adverse events attributed to Essure and nickel sensitization.
Methods:
Patients presenting alleged adverse reactions to Essure were referred for nickel patch testing before removal. Data regarding medical history of nickel sensitization and symptoms attributed to Essure were collected. Dimethylglyoxime spot tests were performed on the explanted Essure. There was a follow-up at 3 months to evaluate whether there is improvement of the symptoms after Essure removal.
Conclusions:
Nickel sensitization via the classic delayed hypersensitivity pathway did not seem to be responsible for adverse events attributed to Essure. Among systemic symptoms reported, extracutaneous symptoms had the highest prevalence. Systemic contact dermatitis to nickel could not be ruled out in one case.
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