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Rapid Microwave-Assisted Cisplatin-Loaded Solid Lipid Nanoparticles: Synthesis, Characterization and Anticancer

Hibah M Aldawsari1, Sima Singh2

  • 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Nanomaterials (Basel, Switzerland)
|March 15, 2020
PubMed
Summary

This study developed novel solid lipid nanoparticles (SLNs) to deliver cisplatin chemotherapy more effectively for breast cancer treatment. The new formulation demonstrated enhanced biocompatibility and targeted drug delivery, improving therapeutic sustainability.

Keywords:
breast cancercisplatinmicrowave-assisted techniquesolid lipid nanoparticlesstearic acid

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Cisplatin is a potent chemotherapy drug for solid tumors.
  • Drug toxicity and resistance limit cisplatin's clinical application.
  • Targeted drug delivery systems are needed to improve cisplatin therapy.

Purpose of the Study:

  • To develop cisplatin-loaded solid lipid nanoparticles (SLNs) for enhanced breast cancer treatment.
  • To evaluate the physicochemical properties and in vitro performance of cisplatin-loaded SLNs.
  • To assess the biocompatibility and cytotoxicity of the novel drug delivery system.

Main Methods:

  • Microwave-assisted, single-step, one-pot synthesis of cisplatin-loaded SLNs.
  • Characterization of SLN size, polydispersity index (PDI), and zeta potential.
  • In vitro drug release studies, hemolysis assay, and cytotoxicity testing on MCF-7 breast cancer cells.

Main Results:

  • Spherical SLNs with a uniform size (74.85 nm) and PDI (0.311) were successfully produced.
  • High encapsulation efficiency (71.85%) and sustained in vitro drug release (80% in 24 h) were achieved.
  • The formulation showed safety in blood (hemolysis assay) and potent cytotoxicity against MCF-7 cells (IC50 = 6.51 μg/mL).

Conclusions:

  • Microwave-assisted SLN formulation provides a promising platform for cisplatin delivery in breast cancer therapy.
  • Cisplatin-loaded SLNs exhibit improved biocompatibility and therapeutic sustainability.
  • This approach offers a potential strategy to overcome cisplatin resistance and reduce toxicity.