Related Experiment Video
Updated: Dec 26, 2025

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
Published on: July 21, 2023
On age-dependent bone remodeling
Areti Papastavrou1, Ina Schmidt1, Kefu Deng2
1Faculty of Mechanical Engineering, Nuremberg Tech, Keßlerplatz 12, 90489 Nuremberg, Germany.
Abstract:
A number of previous studies have investigated the possibilities of modelling the change in density of bones. Remodeling can be formulated at the constitutive or the kinematic level. In this work we introduce a formulation for the density growth process which takes not only the mechanical stimulus into account but also the influence of age on the evolution of growth. We demonstrate the implementation in the context of the finite element method. This novel approach is illustrated for a simple uniaxial extension test and is verified against previous numerical results. Moreover, two further physiologically motivated examples are performed. The results of the proposed modified model show excellent agreement with comparable results from literature and are promising for the application to real-life problems.
Related Concept Videos
Bone Remodeling
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Formation by Endochondral Ossification

