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Adhesion

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...

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Related Experiment Video

Updated: Dec 26, 2025

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

Sticking to the Problem: Engineering Adhesion in Molecular Endoscopic Imaging.

Mahboubeh S Noori¹, Sarah J Bodle^1,2, Christian A Showalter^3,4

¹Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701 USA.

Cellular and Molecular Bioengineering

|March 17, 2020

Summary

Molecular endoscopic imaging (MEI) offers a novel approach for early cancer detection in the esophagus and colon. This technology utilizes molecular ligands to identify cancerous tissue during endoscopy, improving patient survival rates.

Keywords:

Cancer Cell adhesion Colon Dysplasia Endoscopy Esophagus Gastrointestinal

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Last Updated: Dec 26, 2025

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Published on: September 27, 2021

Simultaneously Capturing Real-time Images in Two Emission Channels Using a Dual Camera Emission Splitting System: Applications to Cell Adhesion

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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Area of Science:

Gastroenterology
Oncology
Biomedical Engineering

Background:

Digestive tract cancers cause significant global mortality, with esophageal and colon cancers being major contributors.
Early cancer detection is crucial for improving survival rates, highlighting the need for advanced screening methods.
Current endoscopic screening identifies precancerous and cancerous tissues, but molecular endoscopic imaging (MEI) aims to enhance this process.

Purpose of the Study:

To review ligands and target moieties for molecular endoscopic imaging (MEI) in detecting gastrointestinal cancers.
To explore the biophysical principles governing the efficacy of MEI designs.
To provide a roadmap for developing MEI assays for highly selective in situ recognition of transforming tissues.

Main Methods:

Review of existing literature on ligands and target moieties for MEI.
Analysis of biophysical factors influencing MEI performance.
Analogy drawn between MEI and cell adhesion principles.

Main Results:

Identified potential and investigated ligands and target moieties for MEI applications.
Discussed biophysical considerations critical for successful MEI probe design and tissue interaction.
Established a framework for engineering MEI for precise detection of precancerous and cancerous tissues.

Conclusions:

MEI holds significant promise for the early detection of esophageal and colon cancers by targeting unique biochemical alterations in diseased tissues.
Understanding ligand-target interactions and biophysics is key to optimizing MEI technology.
Further development of MEI can lead to more selective and effective in situ cancer diagnostics.