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Sarcomeric Gene Variants and Their Role with Left Ventricular Dysfunction in Background of Coronary Artery Disease

Surendra Kumar1, Vijay Kumar2, Jong-Joo Kim2

  • 1Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110029, India.

Biomolecules
|March 18, 2020
PubMed

Insights

Coronary artery disease (CAD) can lead to left ventricle dysfunction (LVD). Sarcomeric gene mutations play a key role in LVD, offering new diagnostic and therapeutic avenues for heart failure patients.

Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Cardiovascular diseases, including coronary artery disease (CAD) and hypertension, are leading causes of death globally.
  • Left ventricle dysfunction (LVD) is a common complication in later stages of CAD, significantly impacting prognosis.
  • Left ventricular ejection fraction (LVEF) is a critical prognostic indicator in CAD patients.

Purpose of the Study:

  • To review the role of sarcomeric genes in the development of left ventricle dysfunction (LVD) in patients with coronary artery disease (CAD).
  • To highlight the advancements in genetic diagnosis for cardiac diseases and their implications.
  • To explore the molecular mechanisms underlying LVD in the context of CAD.

Main Methods:

  • Literature review focusing on genetic studies of cardiomyopathies and LVD.
  • Analysis of research on sarcomeric gene mutations.
  • Synthesis of current understanding of genetic factors in CAD-related LVD.

Main Results:

  • Numerous mutations in sarcomeric genes have been identified in various cardiomyopathies.
  • Genetic studies increasingly correlate LVD with conditions like dilated cardiomyopathy (DCM).
  • Progress in genetic identification enhances diagnostic capabilities for cardiac conditions.

Conclusions:

  • Sarcomeric genes are significantly implicated in the pathogenesis of LVD in CAD patients.
  • Genetic insights provide opportunities for improved diagnosis and management of heart failure.
  • Understanding these genetic links is crucial for advancing cardiovascular medicine.

Keywords:
actindilated cardiomyopathyleft ventricle dysfunctionmyosinsarcomeretropomyosintroponin

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