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Updated: Dec 26, 2025

Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice
Published on: July 16, 2015
Application of Focal Photoinduced Thrombosis for Modeling Spinal Cord Ischemia
S S Pashin1, S L Kuznetsov2, N R Pashina2
1Department of Histology, Cytology and Embryology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. pashinss@yandex.ru.
Abstract:
Typical ischemic damage to neurons were detected in the focus of experimental photothrombosis and in the transition zone. They were associated with symptoms of impaired motor functions and dysfunction of pelvic organs. The applied method of focal photothrombosis can be used for simulation of spinal cord ischemia for the development of methods for pharmacological correction and restoration of impaired sensorimotor functions.

