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Murine Fecal Isolation and Microbiota Transplantation
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Microbiome and Cardiovascular Disease.

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Summary
This summary is machine-generated.

Oral and gut microbiota influence atherosclerotic cardiovascular disease (ASCVD) development. Oral bacteria can cause inflammation, while gut microbes affect metabolism and signal pathways, impacting ASCVD progression.

Keywords:
ASCVDAtherosclerosisBacteriophageBile acidsSCFATMAO

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Area of Science:

  • Microbiology
  • Cardiovascular Science
  • Metabolic Research

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a complex systemic disease.
  • Lipoprotein deposition in macrophages initiates plaque formation.
  • Systemic and environmental factors contribute to ASCVD progression.

Purpose of the Study:

  • To critically discuss novel developments in the role of oral and gut microbiota in ASCVD.
  • To explore how microbial communities influence different stages of atherosclerotic plaque formation.

Main Methods:

  • Literature review and critical discussion of emerging research.
  • Analysis of the impact of oral and gut microbiota on host inflammation and metabolism.

Main Results:

  • Oral bacteria translocate to circulation, potentially causing low-grade inflammation, a risk factor for ASCVD.
  • Gut microbiota influence host metabolism, produce metabolites like trimethylamine and short-chain fatty acids.
  • Gut microbes metabolize bile acids into compounds affecting signal transduction pathways.

Conclusions:

  • Both oral and gut microbiota play significant roles in the pathogenesis of ASCVD.
  • Microbial metabolites and inflammatory responses are key mechanisms linking microbiota to ASCVD.
  • Further research into microbiota-targeted interventions for ASCVD is warranted.