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Updated: Dec 26, 2025

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Iron-Catalyzed Silylation of (Hetero)aryl Chlorides with Et3SiBpin
Jia Jia1, Xiaoqin Zeng2, Zhengli Liu2
1Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563003, P. R. China.
Abstract:
To date, the iron-catalyzed construction of C-heteroatom bonds has been less developed due to the difficulty of transmetalation with heteroatom anions and the sluggish reductive elimination. Herein we report an iron-catalyzed method for the silylation of (hetero)aromatic chlorides. It features high efficiency, a broad substrate scope, and excellent functional group compatibility. Moreover, this protocol enables the late-stage silylation of some pharmaceuticals, thus providing an excellent method to access valuable intermediates in medicinal chemistry.
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