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Area of Science:

  • Biomedical Engineering
  • Radiotherapy
  • Ultrasound Imaging

Background:

  • Oxygen microbubbles (OMBs) enhance radiotherapy by oxygenating hypoxic tumors.
  • Intravenous OMB delivery offers theranostic potential via contrast-enhanced ultrasound (CEUS) with minimal invasiveness.
  • Conventional OMBs have short circulation times, limiting their efficacy.

Purpose of the Study:

  • To investigate the impact of phospholipid shell composition and size on OMB circulation persistence.
  • To evaluate OMBs as potential adjuvant agents for radiotherapy and CEUS.

Main Methods:

  • Synthesized OMBs with DSPC (C18:0) and DBPC (C22:0) phospholipid shells.
  • Tested OMBs in three size distributions (0.5-2 µm, 2-10 µm, polydisperse) in mice using CEUS.
  • Assessed circulation half-lives and maximum intensity of different OMB formulations.

Main Results:

  • DBPC OMBs exhibited significantly longer circulation half-lives than DSPC OMBs (2.4 ± 1.0 s vs. 0.6 ± 0.5 s).
  • Larger 2-10 µm OMBs demonstrated increased circulation persistence compared to smaller 0.5-2 µm OMBs.
  • DBPC OMBs showed over tenfold increase in maximum intensity, indicating improved imaging potential.

Conclusions:

  • DBPC-based OMBs with larger sizes (2-10 µm) offer improved circulation persistence and stability.
  • These optimized OMBs hold significant potential as superior adjuvant agents for radiotherapy and CEUS-guided theranostics.