Related Experiment Video
Updated: Dec 25, 2025

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to
Hyojeong Yi1, Jongwook Park1, Kwang-Hwi Cho2
1Division of Biosystems & Biomedical Sciences, College of Health Sciences, Korea University, Seoul, South Korea.
Abstract:
Highly conserved PenI-type class A β-lactamase in pathogenic members of Burkholderia species can evolve to extended-spectrum β-lactamase (ESBL), which exhibits hydrolytic activity toward third-generation cephalosporins, while losing its activity toward the original penicillin substrates. We describe three single-amino-acid-substitution mutations in the ArgS arginine-tRNA synthetase that confer extra antibiotic tolerance protection to ESBL-producing Burkholderia thailandensis This pathway can be exploited to evade antibiotic tolerance induction in developing therapeutic measures against Burkholderia species, targeting their essential aminoacyl-tRNA synthetases.
More Related Videos
Related Concept Videos
Development of Antibiotic Resistance
Antibiotic Selection
Gene Regulation in Microbial Communities: Quorum Sensing
Transduction
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Transcription Attenuation in Prokaryotes
There are several different mechanisms used to attenuate transcription. In ribosome mediated...

