Realistic anatomically detailed open-source spinal cord stimulation (RADO-SCS) model

Area of Science:

• Computational neuroscience
• Biomedical engineering
• Medical device simulation

Background:

• Computational current flow models are crucial for spinal cord stimulation (SCS) device development, clinical trials, and patient programming.
• Existing proprietary models vary in sophistication, highlighting the need for a standardized, high-precision open-source alternative.

Purpose of the Study:

• To develop a sophisticated, open-source SCS modeling platform named Realistic Anatomically Detailed Open-Source Spinal Cord Stimulation (RADO-SCS).
• To establish a standard for SCS simulations with state-of-the-art precision and transparency.

Main Methods:

• Developed the RADO-SCS platform using detailed anatomical data from imaging and cadaveric studies.
• Created a finite element model of the T9-T11 spine levels, incorporating 19 distinct tissue compartments.
• Simulated a bipolar SCS montage to calculate axonal activation thresholds.

Main Results:

• The RADO-SCS model achieves state-of-the-art precision across 19 tissue compartments.
• Calculated electric fields in white and gray matter, and axonal activation thresholds align with previous simulation findings.
• Demonstrated the model's workflow through an exemplary bipolar SCS montage simulation.

Conclusions:

• The RADO-SCS platform enables simulation of any SCS approach with exceptional resolution and reproducibility.
• As a freely available online resource with version control, RADO-SCS will be continuously updated.
• This open-source model serves as a valuable standard for the SCS research community.