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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery
1Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, California 90095, USA. nmaidmen@g.ucla.edu.
Lab on a Chip
|March 27, 2020
Summary
A novel chemical neural probe integrates microfluidics and multi-analyte detection for brain monitoring. This silicon-PDMS hybrid device with an iridium oxide reference electrode shows promise for in-vivo applications.
Area of Science:
- Neuroscience
- Materials Science
- Chemical Engineering
Background:
- Developing advanced neural probes is crucial for understanding brain function.
- Existing probes often lack multi-analyte detection capabilities and integrated microfluidics.
- Silicon-based microelectrode arrays (MEAs) offer a robust platform for neural recording.
Purpose of the Study:
- To fabricate a multifunctional chemical neural probe by combining a microfluidic channel with a silicon-based MEA.
- To enable multi-analyte detection on-probe using enzyme microstamping.
- To validate the performance of the hybrid probe in complex biological environments.
Main Methods:
- Utilized polydimethylsiloxane (PDMS) thin-film transfer for microfluidic integration onto an MEA.
- Employed enzyme microstamping for localized and selective analyte detection.
- Incorporated a nano-based iridium oxide (IrOx) on-probe reference electrode.
- Validated the probe's functionality using brain phantoms and in vivo studies in rat brains.
Main Results:
- Successfully fabricated a silicon/PDMS hybrid chemical neural probe (chemtrode).
- Demonstrated the capability for multi-analyte detection through enzyme microstamping.
- Validated the probe's performance and stability in both simulated (phantoms) and real biological (rat brain) environments.
- The integrated IrOx reference electrode provided stable electrochemical measurements.
Conclusions:
- The developed fabrication process enables the creation of multifunctional neural probes.
- The hybrid chemtrode offers a promising platform for simultaneous electrochemical sensing and neural recording.
- This technology has potential applications in neuroscience research and clinical diagnostics requiring in vivo analyte monitoring.
