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Diagnosing COVID-19: The Disease and Tools for Detection
Buddhisha Udugama1,2, Pranav Kadhiresan1,2, Hannah N Kozlowski1,2
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
ACS Nano
|April 1, 2020
Summary
This review covers diagnostic and surveillance technologies for SARS-CoV-2, the virus causing COVID-19. It highlights emerging point-of-care diagnostics and encourages further technological advancement to combat future epidemics.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- The global spread of COVID-19, caused by SARS-CoV-2, necessitates effective diagnostic and surveillance tools.
- Initial identification of SARS-CoV-2 involved computed tomography, whole genome sequencing, and electron microscopy.
Purpose of the Study:
- To review current and emerging diagnostic and surveillance technologies for SARS-CoV-2.
- To discuss the performance characteristics of these diagnostic methods.
- To encourage the advancement of diagnostic technologies for outbreak management.
Main Methods:
- Review of literature on SARS-CoV-2 diagnostic and surveillance technologies.
- Analysis of performance characteristics of identified technologies.
- Discussion of emerging point-of-care diagnostics.
Main Results:
- Various diagnostic and surveillance technologies exist for SARS-CoV-2 detection.
- Performance characteristics vary among different diagnostic methods.
- Point-of-care diagnostics are under development and show promise.
Conclusions:
- Effective diagnostic and surveillance are crucial for managing the COVID-19 pandemic.
- Advancements in point-of-care diagnostics are needed.
- Developing "plug-and-play" diagnostics can aid in preventing future epidemics.
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