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    A new compact line-field confocal optical coherence tomography (LC-OCT) device using a Mirau interferometer offers high-resolution skin imaging. This advanced LC-OCT provides detailed visualization comparable to larger systems.

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    Area of Science:

    • Biomedical Optics
    • Medical Imaging
    • Optical Coherence Tomography

    Background:

    • Line-field confocal optical coherence tomography (LC-OCT) enables parallel A-scan acquisition using line illumination and detection.
    • High spatial resolution B-scan imaging in LC-OCT is typically achieved via dynamic focusing within a Linnik interferometer.

    Purpose of the Study:

    • To present a novel, compact line-field confocal optical coherence tomography (LC-OCT) device.
    • To evaluate its performance using a custom-designed Mirau interferometer for high-resolution in vivo imaging.

    Main Methods:

    • Development of a compact LC-OCT system incorporating a custom Mirau interferometer.
    • Utilizing line illumination with a broadband laser and line detection with a line-scan camera.
    • Achieving high spatial resolution through dynamic focusing within the Mirau interferometer setup.

    Main Results:

    • The developed LC-OCT device demonstrates comparable spatial resolution and detection sensitivity to existing systems.
    • Achieved in vivo imaging of human skin with a resolution of 1.3 µm (lateral) × 1.1 µm (axial).
    • Imaging was performed over a field of view of 0.9 mm (lateral) × 0.4 mm (axial) at a speed of 12 frames per second.

    Conclusions:

    • The custom-designed Mirau interferometer-based LC-OCT is a viable alternative for high-resolution imaging.
    • The compact and lighter design offers advantages for practical applications in biomedical imaging.
    • This technology enables detailed visualization of biological tissues, such as human skin, with high fidelity.