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Updated: Dec 25, 2025

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
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Diltiazem-associated Photodistributed Hyperpigmentation.

Jacob D Siegel1, Christine J Ko1

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, CT.

The Yale Journal of Biology and Medicine
|April 1, 2020
PubMed
Summary
This summary is machine-generated.

Diltiazem, a hypertension drug, can rarely cause photodistributed hyperpigmentation. This case highlights a 71-year-old woman who developed facial hyperpigmentation after starting diltiazem treatment.

Keywords:
Diltiazemhyperpigmentationinterfacephotodistributed

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Area of Science:

  • Cardiology
  • Dermatology
  • Pharmacology

Background:

  • Diltiazem is a widely prescribed calcium-channel blocker for hypertension.
  • Common side effects include dizziness, headache, and edema.
  • Photodistributed hyperpigmentation is a rare adverse effect of diltiazem.

Observation:

  • A 71-year-old woman presented with new-onset facial hyperpigmentation.
  • The hyperpigmentation appeared 6 months after initiating diltiazem therapy.
  • This is one of fewer than 20 reported cases in the literature.

Findings:

  • The case report details a rare instance of diltiazem-induced hyperpigmentation.
  • Facial hyperpigmentation was the primary dermatological manifestation.
  • The temporal association suggests a link between diltiazem and the observed skin changes.

Implications:

  • Clinicians should be aware of this rare side effect of diltiazem.
  • Early recognition and diagnosis of drug-induced hyperpigmentation are crucial.
  • Further investigation into the mechanisms of diltiazem-associated hyperpigmentation may be warranted.