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Current Developments in the Immunology of Psoriasis.
Franziska Grän1, Andreas Kerstan1, Edgar Serfling2
1Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
The Yale Journal of Biology and Medicine
|April 1, 2020
Summary
Psoriasis is an inflammatory skin disease primarily driven by T cells. Recent research highlights the emerging role of B cells, particularly regulatory B cells, in psoriasis pathogenesis and potential therapeutic strategies.
Area of Science:
- Immunology
- Dermatology
- Pathogenesis of Psoriasis
Background:
- Psoriasis is a common inflammatory skin condition.
- Current understanding emphasizes T lymphocyte involvement in its pathogenesis.
- Innovative therapies have emerged from advancements in skin immunology.
Purpose of the Study:
- To review the pathogenesis of psoriasis, focusing on immune cell roles.
- To discuss current therapeutic developments for psoriasis.
- To highlight the underappreciated role of B cells in psoriasis.
Main Methods:
- Literature review of recent data on psoriasis immunopathology.
- Analysis of the roles of T cells, B cells, and cytokines.
- Discussion of disease development and pathogenicity.
Main Results:
- Psoriasis involves T cells, innate immune cells, and keratinocyte hyperproliferation.
- B cells' role in psoriasis pathogenesis is increasingly recognized.
- Interleukin-10-producing regulatory B cells may ameliorate psoriasis.
Conclusions:
- A comprehensive understanding of psoriasis requires considering both T and B cell contributions.
- Cytokine roles in psoriasis immunopathology are critical.
- Emerging insights into B cell function may lead to novel psoriasis treatments.
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