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Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
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Electrochemically stimulating developments in bioelectronic medicine.

Paola Sanjuan-Alberte1,2, Morgan R Alexander3, Richard J M Hague2

  • 11Regenerative Medicine and Cellular Therapies, School of Pharmacy, University of Nottingham, Nottingham, NG7 2QL UK.

Bioelectronic Medicine
|April 2, 2020
PubMed
Summary
This summary is machine-generated.

Bioelectronic medicine uses electronic devices to control cellular electrical activity for disease treatment. This review explores new electrochemical methods to modulate cell behavior, expanding therapeutic potential beyond neural stimulation.

Keywords:
BioelectrochemistryBioelectronic interfacesCellular signallingNanobioelectronics

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Area of Science:

  • Bioelectronic Medicine
  • Cellular Electrophysiology
  • Electrochemical Engineering

Background:

  • Cellular homeostasis is regulated by electrical activity, offering therapeutic targets.
  • Current bioelectronic technologies primarily focus on neural stimulation, with limitations in precise cellular control.
  • All cells respond to electrical inputs, indicating broader potential for bioelectronic medicine.

Purpose of the Study:

  • To review current electronic methods for modulating cell behavior.
  • To highlight the potential of faradaic currents and electrochemistry in bioelectronic medicine.
  • To identify novel electrochemical strategies for advancing bioelectronic therapeutics.

Main Methods:

  • Review of existing literature on bioelectronic devices and cellular electrophysiology.
  • Analysis of electrochemical principles, specifically faradaic currents generated during redox reactions.
  • Exploration of precedent electrochemical technologies for modulating cellular processes.

Main Results:

  • Existing bioelectronic therapeutics mainly target neural communication.
  • Electronic actuation can program non-excitable cell behavior by altering biological processes.
  • Faradaic currents, generated by redox reactions, represent an underutilized mechanism for cellular control.

Conclusions:

  • Advancements in bioelectronic medicine require improved two-way signaling between electronic and cellular components.
  • Electrochemistry offers new avenues for modulating cell behavior through faradaic currents.
  • Integrating electrochemical techniques can significantly expand the scope and efficacy of bioelectronic therapies for diverse diseases.