Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polarity-Selective Assembly Enables Tough and Stretchable Ionogels for Wearable Electronics.

ACS nano·2026
Same author

Bioinspired spatiotemporal control of microhelix formation and actuation.

Science advances·2026
Same author

Fine structural tuning of the assembly of elastin-collagen peptide conjugates with drug loading and manipulation of molecular interactions.

Biomaterials science·2026
Same author

GANG: Geometrically-Aligned Neural Gaussians for Efficient and Realistic Relighting.

IEEE transactions on visualization and computer graphics·2026
Same author

Comprehensive nutritional metabolomics and transcriptomics reveal varietal differences and drying effects on health-related metabolites in Amomum tsao-ko, a traditional medicinal and culinary plant.

Food research international (Ottawa, Ont.)·2026
Same author

MoGraphGPT: Creating Interactive Scenes Using Modular LLM and Graphical Control.

IEEE transactions on visualization and computer graphics·2026
Same journal

AI-Derived Smart Microneedle Systems for Advanced Wound Management: From Intelligent Sensing to Closed-Loop Therapy.

Macromolecular bioscience·2026
Same journal

A Novel Chitosan-Gelatin Scaffold and Cell Spray Therapy for Treating Limbal Stem Cell Deficiency.

Macromolecular bioscience·2026
Same journal

Electroconductive Soft Microcarriers for Suspension Culture of Skeletal Muscle Cells.

Macromolecular bioscience·2026
Same journal

Dual-Responsive Chitosan-Grafted PNIPAAm Hydrogel Eye Drop Incorporating Insulin-Imprinted Microgels for Dry Eye Syndrome Treatment.

Macromolecular bioscience·2026
Same journal

Levan Inspired Hybrid Composites Materials: Bridging Natural Polysaccharides with Biomedical Technology.

Macromolecular bioscience·2026
Same journal

Anion-Specific Mechanisms in Fibrinogen Self-Assembly: Contrasting Effects of Phosphates and Chlorides in Nanofiber Formation.

Macromolecular bioscience·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.9K

Micromechanical Properties of Microstructured Elastomeric Hydrogels.

Hang Kuen Lau1, Shruti Rattan2, Hongbo Fu2

  • 1Department of Materials Science and Engineering, University of Delaware, 201 DuPont Hall, Newark, DE, 19716, USA.

Macromolecular Bioscience
|April 3, 2020
PubMed
Summary
This summary is machine-generated.

Local micromechanics significantly influence cellular function in biomaterials. This study reveals resilin-like polypeptide (RLP)-poly(ethylene glycol) (PEG) hydrogel properties, showing RLP-rich domains control fracture, aiding tissue regeneration material design.

Keywords:
biopolymerelastomerhydrogelsmechanical propertiesmicrostructure

More Related Videos

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues
11:31

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Published on: August 28, 2014

13.9K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.4K

Related Experiment Videos

Last Updated: Dec 25, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.9K
Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues
11:31

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Published on: August 28, 2014

13.9K
An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
08:17

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

7.4K

Area of Science:

  • Biomaterials Science
  • Mechanobiology
  • Polymer Science

Background:

  • The local micromechanical environment critically affects cellular behavior within heterogeneous hydrogels.
  • Understanding micromechanics is key to designing advanced biomaterials for tissue regeneration.

Purpose of the Study:

  • To characterize the micromechanical properties of microstructured resilin-like polypeptide (RLP)-poly(ethylene glycol) (PEG) hydrogels.
  • To investigate the role of RLP-rich domains in hydrogel deformation and failure.
  • To provide quantitative insights into the micromechanical response of soft hydrogel composites.

Main Methods:

  • Utilized oscillatory shear rheometry, compression dynamic mechanic analysis, and micro/large-strain indentation.
  • Employed confocal microscopy to visualize microstructural deformation during large-strain indentation.
  • Evaluated fracture initiation energy to determine failure mechanisms.

Main Results:

  • Elastic moduli correlated with volume averaging models, with volume fraction dominating low-strain response.
  • RLP-rich domains were observed to translate, rotate, and deform under large strain.
  • Hydrogel fracture initiation energy was controlled by the RLP-rich phase, independent of domain size.

Conclusions:

  • Volume fraction, not domain size, dictates the low-strain mechanical response of RLP-PEG hydrogels.
  • Failure initiation in these composite hydrogels is governed by the RLP-rich phase across multiple domains.
  • This work offers new methods and insights into the micromechanical behavior of soft materials for biomaterial development.